Article

Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers

2025-03-19

Abstract excerpt

<h4>ABSTRACT</h4> A subset of nuclear receptors (NRs) function as permissive heterodimers with retinoid X receptor (RXR), defined by transcriptional activation in response to RXR agonist ligands. Permissive NR-RXR activation is generally understood to operate through a classical pharmacological mechanism in which RXR agonist binding enhances coactivator recruitment to the heterodimer. However, we previously demon...

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Literature Corpus work: 7a1a8ac8-98df-5732-9297-0870df270b4c
DOI: 10.1101/2025.03.19.642122

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