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Article

T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.

The Journal of biological chemistry - 31 May 2002

Lee Gary, Elwood Fabienne, McNally John, Weiszmann Jennifer, Lindstrom Michelle, Amaral Kate, Nakamura Motonao, Miao Shichang, Cao Ping, Learned R Marc, Chen Jin-Long, Li Yang

Abstract excerpt

The nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma (NR1C3)) plays a central role in adipogenesis and is the molecular target for the thiazolidinedione (TZD) class of antidiabetic drugs. In a search for novel non-TZD ligands for PPARgamma, T0070907 was identified as a potent and selective PPARgamma antagonist. With an apparent binding affinity (concentration at 50% inhibition...

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PMID: 11877444
DOI: 10.1074/jbc.M200743200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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