Article

The tumor-maintaining function of UTX/KDM6A in DNA replication and the PARP1-dependent repair pathway

2024-06-03

Abstract excerpt

Histone H3K27 demethylase UTX (aka KDM6A) is mutated in many human cancers, suggesting its tumor suppressive role during cancer development. However, most tumors still express wild-type UTX/KDM6A and its function is not always linked to tumor suppression. Here, we present evidence of UTX/KDM6A’s role in sustaining tumor growth, revealing its function in tumor maintenance. We find that UTX/KDM6A sustains tumor cell...

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Literature Corpus work: 4abda20b-c144-5927-a6e4-a9958b1040ed
DOI: 10.1101/2024.05.31.596824

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