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Article

West Nile Virus fidelity modulates the capacity for host cycling and adaptation.

The Journal of general virology - 1 Apr 2020

Caldwell Haley S, Ngo Kiet, Pata Janice D, Kramer Laura D, Ciota Alexander T

Abstract excerpt

The fidelity of flaviviruses is thought to be tightly regulated for optimal fitness within and between hosts. West Nile virus (WNV) high-fidelity (HiFi) mutations V793I and G806R within the RNA-dependent RNA polymerase, and low-fidelity (LoFi) mutation T248I within the methyltransferase, were previously shown to attenuate infectivity and replicative fitness in Culex mosquitoes and Culex tarsalis (CXT) cells but...

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Identifiers

PMID: 32068528
DOI: 10.1099/jgv.0.001393
PMCID: PMC7414436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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