Article
Arbovirus high fidelity variant loses fitness in mosquitoes and mice.
Proceedings of the National Academy of Sciences of the United States of America - 20 Sept 2011
Coffey Lark L, Beeharry Yasnee, Bordería Antonio V, Blanc Hervé, Vignuzzi Marco
Abstract excerpt
The error rate of RNA-dependent RNA polymerases (RdRp) affects the mutation frequency in a population of viral RNAs. Using chikungunya virus (CHIKV), we describe a unique arbovirus fidelity variant with a single C483Y amino acid change in the nsP4 RdRp that increases replication fidelity and generates populations with reduced genetic diversity. In mosquitoes, high fidelity CHIKV presents lower infection and...
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