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Article

Genetic Drift during Systemic Arbovirus Infection of Mosquito Vectors Leads to Decreased Relative Fitness during Host Switching.

Cell host & microbe - 13 Apr 2016

Grubaugh Nathan D, Weger-Lucarelli James, Murrieta Reyes A, Fauver Joseph R, Garcia-Luna Selene M, Prasad Abhishek N, Black William C, Ebel Gregory D

Abstract excerpt

The emergence of mosquito-borne RNA viruses, such as West Nile virus (WNV), is facilitated by genetically complex virus populations within hosts. Here, we determine whether WNV enzootic (Culex tarsalis, Cx. quinquefasciatus, and Cx. pipiens) and bridge vectors (Aedes aegypti) have differential impacts on viral mutational diversity and fitness. During systemic mosquito infection, WNV faced stochastic reductions in...

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Source

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Identifiers

PMID: 27049584
DOI: 10.1016/j.chom.2016.03.002
PMCID: PMC4833525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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