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Article

Norovirus Polymerase Fidelity Contributes to Viral Transmission In Vivo

20 Oct 2016

Abstract excerpt

Virus replication fidelity and hence the intrahost genetic diversity of viral populations are known to be intricately linked to viral pathogenesis and tropism as well as to immune and antiviral escape during infection. In this study, we investigated whether changes in replication fidelity can impact the ability of a virus to transmit between susceptible hosts by the use of a mouse model for norovirus. We show...

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Identifiers

PMID: 27777985
DOI: 10.1128/msphere.00279-16

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