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Article

Sequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in Mosquitoes.

PLoS pathogens - 1 Jun 2015

Van Slyke Greta A, Arnold Jamie J, Lugo Alex J, Griesemer Sara B, Moustafa Ibrahim M, Kramer Laura D, Cameron Craig E, Ciota Alexander T

Abstract excerpt

High rates of error-prone replication result in the rapid accumulation of genetic diversity of RNA viruses. Recent studies suggest that mutation rates are selected for optimal viral fitness and that modest variations in replicase fidelity may be associated with viral attenuation. Arthropod-borne viruses (arboviruses) are unique in their requirement for host cycling and may necessitate substantial genetic and...

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Source

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Identifiers

PMID: 26114757
DOI: 10.1371/journal.ppat.1005009
PMCID: PMC4482725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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