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Article

TRBP-Dicer interaction may enhance HIV-1 TAR RNA translation via TAR RNA processing, repressing host-cell apoptosis.

Biology open - 25 Feb 2020

Komori Chiaki, Takahashi Tomoko, Nakano Yuko, Ui-Tei Kumiko

Abstract excerpt

The transactivating response (TAR) RNA-binding protein (TRBP) has been identified as a double-stranded RNA (dsRNA)-binding protein, which associates with a stem-loop region known as the TAR element in human immunodeficiency virus-1 (HIV-1). However, TRBP is also known to be an enhancer of RNA silencing, interacting with Dicer, an enzyme that belongs to the RNase III family. Dicer cleaves long dsRNA into small...

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Share to DEAD-box RNA Helicases
Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Long Terminal Repeat

Share to Host-Pathogen Interactions

Share to Protein Biosynthesis

Share to Ribonuclease III

Share to RNA-Binding Proteins

Share to RNA Processing, Post-Transcriptional

Source

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Identifiers

PMID: 32051109
DOI: 10.1242/bio.050435
PMCID: PMC7055394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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