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Article

Helical defects in microRNA influence protein binding by TAR RNA binding protein.

PloS one - 1 Jan 2015

Acevedo Roderico, Orench-Rivera Nichole, Quarles Kaycee A, Showalter Scott A

Abstract excerpt

BACKGROUND: MicroRNAs (miRNAs) are critical post-transcriptional regulators of gene expression. Their precursors have a globally A-form helical geometry, which prevents most proteins from identifying their nucleotide sequence. This suggests the hypothesis that local structural features (e.g., bulges, internal loops) play a central role in specific double-stranded RNA (dsRNA) selection from cellular RNA pools by...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25608000
DOI: 10.1371/journal.pone.0116749
PMCID: PMC4301919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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