The multiple functions of TRBP, at the hub of cell responses to viruses, stress, and cancer.

doi:10.1128/MMBR.00012-12

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Article

The multiple functions of TRBP, at the hub of cell responses to viruses, stress, and cancer.

Microbiology and molecular biology reviews : MMBR - 1 Sept 2012

Daniels Sylvanne M, Gatignol Anne

Abstract excerpt

The TAR RNA binding protein (TRBP) has emerged as a key player in many cellular processes. First identified as a cellular protein that facilitates the replication of human immunodeficiency virus, TRBP has since been shown to inhibit the activation of protein kinase R (PKR), a protein involved in innate immune responses and the cellular response to stress. It also binds to the PKR activator PACT and regulates its...

Topics

Cells
Gene Expression Regulation
Heat-Shock Response
Humans
Mutation
Neoplasms
RNA-Binding Proteins
Virus Diseases
Viruses

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Identifiers

PMID: 22933564
DOI: 10.1128/MMBR.00012-12
PMCID: PMC3429622

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