Article
Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression.
The Journal of biological chemistry - 7 Sept 2001
Daher A, Longuet M, Dorin D, Bois F, Segeral E, Bannwarth S, Battisti P L, Purcell D F, Benarous R, Vaquero C, Meurs E F, Gatignol A
Abstract excerpt
Trans-activation response (TAR) RNA-binding protein (TRBP) is a cellular protein that binds to the human immunodeficiency virus-1 (HIV-1) TAR element RNA. It has two double-stranded RNA binding domains (dsRBDs), but only one is functional for TAR binding. TRBP interacts with the interferon-induced protein kinase R (PKR) and inhibits its activity. We used the yeast two-hybrid assay to map the interaction sites...
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