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Article

A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function.

Nature genetics - 1 Mar 2009

Melo Sonia A, Ropero Santiago, Moutinho Catia, Aaltonen Lauri A, Yamamoto Hiroyuki, Calin George A, Rossi Simona, Fernandez Agustin F, Carneiro Fatima, Oliveira Carla, Ferreira Bibiana, Liu Chang-Gong, Villanueva Alberto, Capella Gabriel, Schwartz Simo, Shiekhattar Ramin, Esteller Manel

Abstract excerpt

microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by targeting messenger RNA (mRNA) transcripts. Recently, a miRNA expression profile of human tumors has been characterized by an overall miRNA downregulation. Explanations for this observation include a failure of miRNA post-transcriptional regulation, transcriptional silencing associated with hypermethylation of CpG island promoters and...

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Topics

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Share to Cell Survival
Share to DEAD-box RNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to HCT116 Cells

Share to Mice, Nude

Share to Ribonuclease III

Share to RNA-Binding Proteins

Share to RNA Processing, Post-Transcriptional

Source

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Identifiers

PMID: 19219043
DOI: 10.1038/ng.317
PMCID: PMC4509508

Genes

DICER1
TARBP2

Provenance

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A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function.PMID 19219043Read ↗

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