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Article

Opposite actions of two dsRNA-binding proteins PACT and TRBP on RIG-I mediated signaling.

The Biochemical journal - 12 Feb 2021

Vaughn Lauren S, Chukwurah Evelyn, Patel Rekha C

Abstract excerpt

An integral aspect of innate immunity is the ability to detect foreign molecules of viral origin to initiate antiviral signaling via pattern recognition receptors (PRRs). One such receptor is the RNA helicase retinoic acid inducible gene 1 (RIG-I), which detects and is activated by 5'triphosphate uncapped double stranded RNA (dsRNA) as well as the cytoplasmic viral mimic dsRNA polyI:C. Once activated, RIG-I's...

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Identifiers

PMID: 33459340
DOI: 10.1042/BCJ20200987
PMCID: PMC7919947

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