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Article

T-cell senescence accelerates angiotensin II-induced target organ damage.

Cardiovascular research - 1 Jan 2021

Pan Xiao-Xi, Wu Fang, Chen Xiao-Hui, Chen Dong-Rui, Chen Hong-Jin, Kong Ling-Ran, Ruan Cheng-Chao, Gao Ping-Jin

Abstract excerpt

AIMS: Aging is a risk factor for cardiovascular diseases and adaptive immunity has been implicated in angiotensin (Ang) II-induced target organ dysfunction. Herein, we sought to determine the role of T-cell senescence in Ang II-induced target organ impairment and to explore the underlying mechanisms. METHODS AND RESULTS: Flow cytometric analysis revealed that T cell derived from aged mice exhibited...

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PMID: 32049355
DOI: 10.1093/cvr/cvaa032

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