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Article

Involvement of Senescence and Mitochondrial Fission in Endothelial Cell Pro-Inflammatory Phenotype Induced by Angiotensin II.

International journal of molecular sciences - 28 Apr 2020

Miyao Masashi, Cicalese Stephanie, Kawai Tatsuo, Cooper Hannah A, Boyer Michael J, Elliott Katherine J, Forrester Steven J, Kuroda Ryohei, Rizzo Victor, Hashimoto Tomoki, Scalia Rosario, Eguchi Satoru

Abstract excerpt

Angiotensin II (AngII) has a crucial role in cardiovascular pathologies, including endothelial inflammation and premature vascular aging. However, the precise molecular mechanism underlying aging-related endothelial inflammation induced by AngII remains elusive. Here, we have tested a hypothesis in cultured rat aortic endothelial cells (ECs) that the removal of AngII-induced senescent cells, preservation of...

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Identifiers

PMID: 32354103
DOI: 10.3390/ijms21093112
PMCID: PMC7247685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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