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Article

Senescent CD8+ T cells: a novel risk factor in atrial fibrillation.

Cardiovascular research - 15 Apr 2025

Li Xiang, Bao Yangyang, Zhang Ning, Lin Changjian, Xie Yun, Wei Yue, Luo Qingzhi, Liu Jingmeng, Sha Zimo, Wu Guanhua, Zhou Taojie, Chen Qiujing, Ling Tianyou, Pan Wenqi, Lu Lin, Wu Liqun, Dai Yang, Jin Qi

Abstract excerpt

AIMS: Immune cell alterations may play a role in the development of atrial fibrillation (AF). Our objective was to comprehensively characterize immune cells in AF, and investigate the potential mechanisms. METHODS AND RESULTS: Single-cell RNA sequencing and multicolour flow cytometry revealed that T cells constituted the most significant subset alterations in AF, and senescent CD8+ T cells were AF-associated...

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PMID: 39382426
DOI: 10.1093/cvr/cvae222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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