Article

Clearance of senescent cells following cardiac ischemia-reperfusion injury improves recovery

2020-04-28

Abstract excerpt

A key component of cardiac ischemia-reperfusion injury (IRI) is the increased generation of reactive oxygen species, leading to enhanced inflammation and tissue dysfunction in patients following intervention for myocardial infarction. In this study we hypothesized that oxidative stress, due to ischemia-reperfusion, induces senescence which contributes to the pathophysiology of cardiac IRI. We demonstrate that IRI...

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Literature Corpus work: c4c88d29-71d8-5cc1-910a-c196ca0f1968
DOI: 10.1101/2020.04.28.065789

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