Article
Immunosenescence increases the rate of acceptance of kidney allotransplants in elderly recipients through exhaustion of CD4+ T-cells.
Mechanisms of ageing and development - 1 Feb 2010
Trzonkowski Piotr, Debska-Slizień Alicja, Jankowska Magdalena, Wardowska Anna, Carvalho-Gaspar Manuela, Hak Łukasz, Moszkowska Grazyna, Bzoma Beata, Mills Natalie, Wood Kathryn J, Myśliwska Jolanta, Rutkowski Bolesław
Abstract excerpt
Compromised immunity is the hallmark of ageing. Paradoxically, it may be "an ally" in facilitating acceptance of allogeneic grafts in the elderly. In this retrospective study we looked for biomarkers of immunosenescence that distinguish elderly recipients less prone to reject kidney allografts. Recruited kidney recipients aged > or = 60 or < 60 were designated 'elderly' and 'young', respectively. Both age-groups...
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