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Article

The aging kidney is characterized by tubuloinflammaging, a phenotype associated with MHC-II gene expression.

Frontiers in immunology - 1 Jan 2023

Sinning Julius, Funk Nils David, Soerensen-Zender Inga, Wulfmeyer Vera Christine, Liao Chieh Ming, Haller Hermann, Hinze Christian, Schmidt-Ott Kai Martin, Melk Anette, Schmitt Roland

Abstract excerpt

Introduction: Even during physiologic aging, the kidney experiences a loss of mass and a progressive functional decline. This is clinically relevant as it leads to an increased risk of acute and chronic kidney disease. The kidney tubular system plays an important role in the underlying aging process, but the involved cellular mechanisms remain largely elusive. Methods: Kidneys of 3-, 12- and 24-month-old male...

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Identifiers

PMID: 37675124
DOI: 10.3389/fimmu.2023.1222339
PMCID: PMC10477980

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