Stress-induced β cell early senescence confers protection against type 1 diabetes

Abstract excerpt

During the progression of type 1 diabetes (T1D), β cells are exposed to significant stress and, therefore, require adaptive responses to survive. The adaptive mechanisms that can preserve β cell function and survival in the face of autoimmunity remain unclear. Here, we show that the deletion of the unfolded protein response (UPR) genes Atf6α or Ire1α in β cells of non-obese diabetic (NOD) mice prior to insulitis...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Diabetes and associated disorders
• Share to Endoplasmic Reticulum Stress and Disease
• Share to Pancreatic function and diabetes