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Article

Increased T cell immunosenescence and accelerated maturation phenotypes in older kidney transplant recipients.

Human immunology - 1 Sept 2018

Schaenman J M, Rossetti M, Sidwell T, Groysberg V, Sunga G, Korin Y, Liang E, Zhou X, Abdalla B, Lum E, Bunnapradist S, Pham T, Danovitch G, Reed E F

Abstract excerpt

Older kidney transplant recipients experience increased rates of infection and death, and less rejection, compared with younger patients. However, little is known about immune dysfunction in older compared with younger kidney transplant recipients and whether it is associated with infection. We evaluated T cell phenotypes including maturation, immune senescence, and exhaustion in a novel investigation into...

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Identifiers

PMID: 29913200
DOI: 10.1016/j.humimm.2018.06.006
PMCID: PMC6429965

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KLRG1

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