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Article

A novel motif in the yeast mitochondrial dynamin Dnm1 is essential for adaptor binding and membrane recruitment.

The Journal of cell biology - 12 Nov 2012

Bui Huyen T, Karren Mary A, Bhar Debjani, Shaw Janet M

Abstract excerpt

To initiate mitochondrial fission, dynamin-related proteins (DRPs) must bind specific adaptors on the outer mitochondrial membrane. The structural features underlying this interaction are poorly understood. Using yeast as a model, we show that the Insert B domain of the Dnm1 guanosine triphosphatase (a DRP) contains a novel motif required for association with the mitochondrial adaptor Mdv1. Mutation of this...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23148233
DOI: 10.1083/jcb.201207079
PMCID: PMC3494853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel motif in the yeast mitochondrial dynamin Dnm1 is essential for adaptor binding and membrane recruitment.PMID 23148233Read ↗

The GTPase effector domain sequence of the Dnm1p GTPase regulates self-assembly and controls a rate-limiting step in mitochondrial fission.Semantic proximity Read ↗

Mimicking human Drp1 disease-causing mutations in yeast Dnm1 reveals altered mitochondrial dynamics.Semantic proximity Read ↗

Structural basis for recruitment of mitochondrial fission complexes by Fis1.Semantic proximity Read ↗

Intra- and intermolecular domain interactions of the C-terminal GTPase effector domain of the multimeric dynamin-like GTPase Drp1.Semantic proximity Read ↗

An intermembrane space protein facilitates completion of mitochondrial division in yeastSemantic proximity Read ↗

Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1.Semantic proximity Read ↗

The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria.Semantic proximity Read ↗

Mdv1 interacts with assembled dnm1 to promote mitochondrial division.Semantic proximity Read ↗

Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p.Semantic proximity Read ↗

A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher order assembly and mitochondrial division.Semantic proximity Read ↗

Mitochondria-specific function of the dynamin family protein DLP1 is mediated by its C-terminal domains.Semantic proximity Read ↗

Disease-associated mutations in Drp1 have fundamentally different effects on the mitochondrial fission machinery.Semantic proximity Read ↗

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