Article
Role of Mfd and GreA in Bacillus subtilis Base Excision Repair-Dependent Stationary-Phase Mutagenesis.
Journal of bacteriology - 9 Apr 2020
Leyva-Sánchez Hilda C, Villegas-Negrete Norberto, Abundiz-Yañez Karen, Yasbin Ronald E, Robleto Eduardo A, Pedraza-Reyes Mario
Abstract excerpt
We report that the absence of an oxidized guanine (GO) system or the apurinic/apyrimidinic (AP) endonucleases Nfo, ExoA, and Nth promoted stress-associated mutagenesis (SAM) in Bacillus subtilis YB955 (hisC952 metB5 leuC427). Moreover, MutY-promoted SAM was Mfd dependent, suggesting that transcriptional transactions over nonbulky DNA lesions promoted error-prone repair. Here, we inquired whether Mfd and GreA,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
