Article
Roles of endonuclease V, uracil-DNA glycosylase, and mismatch repair in Bacillus subtilis DNA base-deamination-induced mutagenesis.
Journal of bacteriology - 1 Jan 2012
López-Olmos Karina, Hernández Martha P, Contreras-Garduño Jorge A, Robleto Eduardo A, Setlow Peter, Yasbin Ronald E, Pedraza-Reyes Mario
Abstract excerpt
The disruption of ung, the unique uracil-DNA-glycosylase-encoding gene in Bacillus subtilis, slightly increased the spontaneous mutation frequency to rifampin resistance (Rif(r)), suggesting that additional repair pathways counteract the mutagenic effects of uracil in this microorganism. An alternative excision repair pathway is involved in this process, as the loss of YwqL, a putative endonuclease V homolog,...
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