Article
The bacterial DNA repair protein Mfd confers resistance to the host nitrogen immune response.
Scientific reports - 20 Jul 2016
Guillemet Elisabeth, Leréec Alain, Tran Seav-Ly, Royer Corinne, Barbosa Isabelle, Sansonetti Philippe, Lereclus Didier, Ramarao Nalini
Abstract excerpt
Production of reactive nitrogen species (NO) is a key step in the immune response following infections. NO induces lesions to bacterial DNA, thus limiting bacterial growth within hosts. Using two pathogenic bacteria, Bacillus cereus and Shigella flexneri, we show that the DNA-repair protein Mfd (Mutation-Frequency-Decline) is required for bacterial resistance to the host-NO-response. In both species, a mutant...
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