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Article

Transcriptional coupling (Mfd) and DNA damage scanning (DisA) coordinate excision repair events for efficient Bacillus subtilis spore outgrowth.

MicrobiologyOpen - 1 Oct 2018

Valenzuela-García Luz I, Ayala-García Víctor M, Regalado-García Ana G, Setlow Peter, Pedraza-Reyes Mario

Abstract excerpt

The absence of base excision repair (BER) proteins involved in processing ROS-promoted genetic insults activates a DNA damage scanning (DisA)-dependent checkpoint event in outgrowing Bacillus subtilis spores. Here, we report that genetic disabling of transcription-coupled repair (TCR) or nucleotide excision repair (NER) pathways severely affected outgrowth of ΔdisA spores, and much more so than the effects of...

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Identifiers

PMID: 29536659
DOI: 10.1002/mbo3.593
PMCID: PMC6182552

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