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Article

Parallel Strategy Increases the Thermostability and Activity of Glutamate Decarboxylase.

Molecules (Basel, Switzerland) - 6 Feb 2020

Zhang Qing-Fei, Hu Sheng, Zhao Wei-Rui, Huang Jun, Mei Jia-Qi, Mei Le-He

Abstract excerpt

Glutamate decarboxylase (GAD; EC 4.1.1.15) is a unique pyridoxal 5-phosphate (PLP)-dependent enzyme that specifically catalyzes the decarboxylation of L-glutamic acid to produce γ-aminobutyric acid (GABA), which exhibits several well-known physiological functions. However, glutamate decarboxylase from different sources has the common problem of poor thermostability that affects its application in industry. In...

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PMID: 32041144
DOI: 10.3390/molecules25030690
PMCID: PMC7037157

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