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Article

Expanding the active pH range of Escherichia coli glutamate decarboxylase by breaking the cooperativeness.

Journal of bioscience and bioengineering - 1 Feb 2013

Thu Ho Ngoc Anh, Hou Chen Yuan, Kim Woo Hyun, Kang Taek Jin

Abstract excerpt

Bacterial glutamate decarboxylase (GAD) transforms glutamate into γ-aminobutyric acid (GABA) with the consumption of a proton. The enzyme is active under acidic environments only and sharply loses its activity as pH approaches neutrality with concomitant structural deformation. In an attempt to understand better the role of this cooperative loss of activity upon pH shifts, we prepared and studied a series of GAD...

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Source

Identifiers

PMID: 23026450
DOI: 10.1016/j.jbiosc.2012.09.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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