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Improving the Thermostability of Glutamate Decarboxylase from Lactobacillus brevis by Consensus Mutagenesis.

Applied biochemistry and biotechnology - 1 Aug 2020

Hua Yujiao, Lyu Changjiang, Liu Chunyan, Wang Hongpeng, Hu Sheng, Zhao Weirui, Mei Jiaqi, Huang Jun, Mei Lehe

Abstract excerpt

γ-Aminobutyrate (GABA) is an important bioactive compound synthesized through decarboxylation of L-glutamate by the glutamate decarboxylase (GAD). In this study, stabilized variants of the GAD from Lactobacillus brevis were constructed by consensus mutagenesis. Using Consensus Finder ( http://cbs-kazlab.oit.umn.edu/ ), eight positions with the most prevalent amino acid (over 60% threshold) among the homologous...

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PMID: 32124175
DOI: 10.1007/s12010-020-03283-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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