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Article

Enhancing the thermostability of fumarase C from Corynebacterium glutamicum via molecular modification.

Enzyme and microbial technology - 1 Aug 2018

Lin Ling, Wang Ying, Wu Mianbin, Zhu Li, Yang Lirong, Lin Jianping

Abstract excerpt

Fumarases have been successfully applied in industry for the production of l-malate. However, the industrialization of fumarases is limited by their low thermostability. In this study, the thermostability of fumarase C from Corynebacterium glutamicum was enhanced through directed evolution, simulated mutagenesis, site-directed mutagenesis and saturated mutagenesis. Mutant 2G (A411V) was initially constructed...

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Identifiers

PMID: 29859602
DOI: 10.1016/j.enzmictec.2018.04.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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