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Article

[Enhancing glutamate decarboxylase activity by site-directed mutagenesis: an insight from Ramachandran plot].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology - 1 Jan 2016

Ke Piyu, Huang Jun, Hu Sheng, Zhao Weirui, Lü Changjiang, Yu Kai, Lei Yinlin, Wang Jinbo, Mei Lehe

Abstract excerpt

Glutamate decarboxylase (GAD) can catalyze the decarboxylation of glutamate into γ-aminobutyrate (GABA) and is the only enzyme of GABA biosynthesis. Improving GAD activity and thermostability will be helpful for the highly efficient biosynthesis of GABA. According to the Ramachandran plot information of GAD 1407 three-dimensional structure from Lactobacillus brevis CGMCC No. 1306, we identified the unstable site...

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PMID: 27443004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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