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Article

Enhancement of glutaminase production through protein design and host strain modification in Bacillus amyloliquefaciens.

Journal of biotechnology - 1 Aug 2026

Zou Dian, Ding Xiaoqi, Bao Pengfei, Ji Anying, Mao Zejing, Zheng Xianliang, Wei Xuetuan

Abstract excerpt

Glutaminase catalyzes the hydrolysis of γ-glutamyl groups to produce glutamic acid and ammonia, exhibiting broad-spectrum applications in food processing, fine chemicals, and pharmaceutical industries. However, its limited production efficiency constrains its industrial application. In this study, a small mutant library was constructed by rational protein design. Mutant strain HZ-12/pHY-glu3 (S467H) displayed a...

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PMID: 42140562
DOI: 10.1016/j.jbiotec.2026.05.006

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