Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted Deletion of Integrin-Linked Kinase Reveals a Role in T-Cell Chemotaxis and Survival

28 Nov 2005

Abstract excerpt

Integrin-linked kinase (ILK) is a serine/threonine kinase that is important in cell-matrix interactions and cell signaling. To examine the role of ILK in leukocyte trafficking and survival, we generated T cell-specific ILK knockouts by breeding ILK(flox/flox) mice to transgenic mice expressing Cre recombinase under control of the Lck proximal promoter. Thymic T cells from Lck-Cre(+)/ILK(flox/flox) mice had a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Phagocytosis and Immune Regulation
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16314534
DOI: 10.1128/mcb.25.24.11145-11155.2005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted Deletion of Integrin-Linked Kinase Reveals a Role in T-Cell Chemotaxis and SurvivalPMID 16314534Read ↗

Integrin-linked kinase – essential roles in physiology and cancer biologySemantic proximity Read ↗

The role of integrin-linked kinase (ILK) in cancer progression.Semantic proximity Read ↗

ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling.Semantic proximity Read ↗

Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation.Semantic proximity Read ↗

Deletion of integrin-linked kinase from skeletal muscles of mice resembles muscular dystrophy due to alpha 7 beta 1-integrin deficiency.Semantic proximity Read ↗

LCK deficiency in CD8 T cells leads to reduced proliferation and increased effector T-cell formation in miceSemantic proximity Read ↗

A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1–mediated adhesion in T cellsSemantic proximity Read ↗

Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice.Semantic proximity Read ↗

Integrin-linked kinase at a glanceSemantic proximity Read ↗

Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration.Semantic proximity Read ↗

Integrin-linked kinase: not so 'pseudo' after all.Semantic proximity Read ↗

Deletion of integrin-linked kinase from neural crest cells in mice results in aortic aneurysms and embryonic lethality.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.