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Article

Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18.

eLife - 7 Feb 2020

Liu Huan, Duncan Kaylia, Helverson Annika, Kumari Priyanka, Mumm Camille, Xiao Yao, Carlson Jenna Colavincenzo, Darbellay Fabrice, Visel Axel, Leslie Elizabeth, Breheny Patrick, Erives Albert J, Cornell Robert A

Abstract excerpt

Genome-wide association studies for non-syndromic orofacial clefting (OFC) have identified single nucleotide polymorphisms (SNPs) at loci where the presumed risk-relevant gene is expressed in oral periderm. The functional subsets of such SNPs are difficult to predict because the sequence underpinnings of periderm enhancers are unknown. We applied ATAC-seq to models of human palate periderm, including zebrafish...

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Share to Enhancer Elements, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Green Fluorescent Proteins

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Share to Polymorphism, Single Nucleotide

Share to Regulatory Sequences, Nucleic Acid

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Source

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Identifiers

PMID: 32031521
DOI: 10.7554/eLife.51325
PMCID: PMC7039683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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