“Integration of multimodal data in the developing tooth reveals candidate dental disease genes”

Abstract excerpt

Dental malformations range from rare syndromes to common nonsyndromic phenotypes. These malformations can predispose individuals to dental disease, which can in turn affect systemic health. While many dental phenotypes are heritable, most cases have not been linked to deleterious mutations in single genes. We demonstrate that human and conserved mouse craniofacial enhancers show enrichment of dental phenotype-asso...

Topics

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• Asymptomatic Diseases
• Bone and Bones
• Cleft Lip
• Cleft Palate
• MSX1 Transcription Factor
• Mutation
• Pregnancy
• Transcriptome

Identifiers and source

Literature Corpus work

4fc5f174-a056-5a15-8ee9-5900fbb94d70

DOI

10.1101/2022.03.15.483501