Back to search

Article

Conservation of transcriptional regulatory networks in zebrafish and human periderm facilitates identification of <i>GRHL1</i> as an orofacial cleft risk gene

2026-04-30

Abstract excerpt

Most heritable risk for orofacial clefts (OFC) remains unassigned to specific genes or loci. IRF6 and GRHL3 , two established OFC risk genes, encode transcription factors (TFs) essential for the differentiation of the periderm, a transient embryonic tissue required for secondary palate fusion. To identify novel risk candidates, we modeled the zebrafish periderm transcriptional regulatory network (TRN). Using sin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ba9b06ab-0bcf-53c1-9fb4-575a75e27475
DOI
10.64898/2026.04.27.720742
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Conservation of transcriptional regulatory networks in zebrafish and human periderm facilitates identification of <i>GRHL1</i> as an orofacial cleft risk geneDOI 10.64898/2026.04.27.720742
Irf6 directly regulates Klf17 in zebrafish periderm and Klf4 in murine oral epithelium, and dominant-negative KLF4 variants are present in patients with cleft lip and palate.Semantic proximity
Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human <i>KRT8/18</i>Semantic proximity
Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18.Semantic proximity
Integrative analysis of transcriptomics in human craniofacial development reveals novel candidate disease genesSemantic proximity
Time-resolved inference of gene regulatory networks underlying human cranial neural crest development suggests novel risk genes for orofacial cleftingSemantic proximity
Genetic-epigenetic interactions (meQTLs) in orofacial clefts etiologySemantic proximity
Comprehensive analysis of <i>de novo</i> variants across 2,497 orofacial cleft trios reveals novel genetic drivers of diseaseSemantic proximity
Rare variants in PRKCI cause Van der Woude syndrome and other features of peridermopathy.Semantic proximity
An integrative, genomic, transcriptomic and network-assisted study to identify genes associated with human cleft lip with or without cleft palate.Semantic proximity
Rare variants in PRKCI cause Van der Woude syndrome and other features of peridermopathySemantic proximity
Functional annotation of de novo variants found near GWAS loci associated with cleft lip with or without cleft palateSemantic proximity
Variants in CALD1, ESRP1, and RBFOX1 are associated with orofacial cleft risk.Semantic proximity
Select a neighboring publication to make it the new centre.