Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural features of vps35p involved in interaction with other subunits of the retromer complex.

Traffic (Copenhagen, Denmark) - 1 Dec 2007

Restrepo Ricardo, Zhao Xiang, Peter Harald, Zhang Bao-Yan, Arvan Peter, Nothwehr Steven F

Abstract excerpt

The penta-subunit retromer complex of yeast mediates selective retrieval of membrane proteins from the prevacuolar endosome to the trans Golgi network. In this study, we set out to generate a panel of vps35 dominant-negative mutants that disrupt retromer-mediated cargo sorting. Mapping of the mutations revealed two types of alterations leading to dominant-negative behavior of the 944-amino acid protein: (i)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier Proteins
Share to Codon
Share to Endosomes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Dominant

Share to Protein Transport

Share to Saccharomyces cerevisiae Proteins

Share to trans-Golgi Network

Share to Vesicular Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 17892535
DOI: 10.1111/j.1600-0854.2007.00659.x
PMCID: PMC2504507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural features of vps35p involved in interaction with other subunits of the retromer complex.PMID 17892535Read ↗

Dominant-negative behavior of mammalian Vps35 in yeast requires a conserved PRLYL motif involved in retromer assembly.Semantic proximity Read ↗

Identification of a conserved motif required for Vps35p/Vps26p interaction and assembly of the retromer complex.Semantic proximity Read ↗

Vps26p, a component of retromer, directs the interactions of Vps35p in endosome-to-Golgi retrieval.Semantic proximity Read ↗

Retromer's Role in Endosomal Trafficking and Impaired Function in Neurodegenerative Diseases.Semantic proximity Read ↗

env1 Mutant of VPS35 gene exhibits unique protein localization and processing phenotype at Golgi and lysosomal vacuole in Saccharomyces cerevisiae.Semantic proximity Read ↗

Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase.Semantic proximity Read ↗

Sorting of yeast membrane proteins into an endosome-to-Golgi pathway involves direct interaction of their cytosolic domains with Vps35p.Semantic proximity Read ↗

The VPS35 protein and the role of its impairments in mitochondrial dysfunction in Parkinson's disease.Semantic proximity Read ↗

Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins.Semantic proximity Read ↗

Arabidopsis VPS35, a retromer component, is required for vacuolar protein sorting and involved in plant growth and leaf senescence.Semantic proximity Read ↗

Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products.Semantic proximity Read ↗

Mammalian Retromer Is an Adaptable Scaffold for Cargo Sorting from Endosomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.