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Article

Vacuolar protein sorting: two different functional states of the AAA-ATPase Vps4p.

Journal of molecular biology - 21 Mar 2008

Hartmann Claudia, Chami Mohamed, Zachariae Ulrich, de Groot Bert L, Engel Andreas, Grütter Markus G

Abstract excerpt

The vacuolar protein sorting (Vps) pathway, in which Vps4 class I AAA-ATPases play a central role, regulates growth factor receptors, immune response, and developmental signaling, and participates in tumor suppression, apoptosis, and retrovirus budding. We present the first atomic structure of the nucleotide-free yeast His(6)DeltaNVps4p dimer and its AMPPNP (5'-adenylyl-beta,gamma-imidodiphosphate)-bound...

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Share to Adenosine Triphosphatases
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Endosomal Sorting Complexes Required for Transport

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Source

Identifiers

PMID: 18272179
DOI: 10.1016/j.jmb.2008.01.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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