Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2020

Kralova Jarmila, Drobek Ales, Prochazka Jan, Spoutil Frantisek, Fabisik Matej, Glatzova Daniela, Borna Simon, Pokorna Jana, Skopcova Tereza, Angelisova Pavla, Gregor Martin, Kovarik Pavel, Sedlacek Radislav, Brdicka Tomas

Abstract excerpt

Autoinflammatory diseases are characterized by dysregulation of the innate immune system, leading to spontaneous inflammation. Pstpip2cmo mouse strain is a well-characterized model of this class of disorders. Because of the mutation leading to the lack of adaptor protein PSTPIP2, these animals suffer from autoinflammatory chronic multifocal osteomyelitis similar to several human syndromes. Current evidence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Bones
Share to Cytoskeletal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-1beta

Share to NADPH Oxidase 2

Share to Neutrophils

Share to Osteomyelitis

Share to Primary Cell Culture

Share to Superoxides

Source

Identifiers

PMID: 32024700
DOI: 10.4049/jimmunol.1900953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis.PMID 32024700Read ↗

Regulation of neutrophil NADPH oxidase by PSTPIP2 affects bone damage in murine autoinflammatory osteomyelitisSemantic proximity Read ↗

Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice.Semantic proximity Read ↗

NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β–mediated osteomyelitisSemantic proximity Read ↗

Increased neutrophil infiltration, IL-1 production and a SAPHO syndrome-like phenotype in PSTPIP2-deficient mice.Semantic proximity Read ↗

Critical role for inflammasome-independent IL-1β production in osteomyelitis.Semantic proximity Read ↗

PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts.Semantic proximity Read ↗

Depicting pathogenesis of osteomyelitis by single cell RNA-sequencing and an involvement of <i>Morrbid</i> in the autoinflammatory diseaseSemantic proximity Read ↗

Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory diseaseSemantic proximity Read ↗

The Nox2 NADPH oxidase regulates neutrophilic inflammation in the oral cavitySemantic proximity Read ↗

Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice.Semantic proximity Read ↗

Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.Semantic proximity Read ↗

Lack of p47(phox) in Akita Diabetic Mice Is Associated with Interstitial Pneumonia, Fibrosis, and Oral Inflammation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.