Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Critical role for inflammasome-independent IL-1β production in osteomyelitis.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jan 2014

Lukens John R, Gross Jordan M, Calabrese Christopher, Iwakura Yoichiro, Lamkanfi Mohamed, Vogel Peter, Kanneganti Thirumala-Devi

Abstract excerpt

The immune system plays an important role in the pathophysiology of many acute and chronic bone disorders, but the specific inflammatory networks that regulate individual bone disorders remain to be elucidated. Here, we characterized the osteoimmunological underpinnings of osteolytic bone disease in Pstpip2(cmo) mice. These mice carry a homozygous L98P missense mutation in the Pombe Cdc15 homology family...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Diseases
Share to Caspase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammasomes

Share to Interleukin-1

Share to Osteoblasts

Share to Osteoclasts

Share to Osteomyelitis

Share to X-Ray Microtomography

Source

Open in PubMed Open full text

Identifiers

PMID: 24395792
DOI: 10.1073/pnas.1318688111
PMCID: PMC3903206

Genes

PSTPIP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Critical role for inflammasome-independent IL-1β production in osteomyelitis.PMID 24395792Read ↗

NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β–mediated osteomyelitisSemantic proximity Read ↗

Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice.Semantic proximity Read ↗

Regulation of neutrophil NADPH oxidase by PSTPIP2 affects bone damage in murine autoinflammatory osteomyelitisSemantic proximity Read ↗

Increased neutrophil infiltration, IL-1 production and a SAPHO syndrome-like phenotype in PSTPIP2-deficient mice.Semantic proximity Read ↗

Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis.Semantic proximity Read ↗

Depicting pathogenesis of osteomyelitis by single cell RNA-sequencing and an involvement of <i>Morrbid</i> in the autoinflammatory diseaseSemantic proximity Read ↗

PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts.Semantic proximity Read ↗

A novel murine model of early calcium pyrophosphate deposition disease based on the TNFRSF11B mutation mimics features of the human disease.Semantic proximity Read ↗

Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cellsSemantic proximity Read ↗

Autoinflammatory bone disorders.Semantic proximity Read ↗

Update on the genetics of nonbacterial osteomyelitis in humans.Semantic proximity Read ↗

Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.