Article
Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jan 2014
Cassel Suzanne L, Janczy John R, Bing Xinyu, Wilson Shruti P, Olivier Alicia K, Otero Jesse E, Iwakura Yoichiro, Shayakhmetov Dmitry M, Bassuk Alexander G, Abu-Amer Yousef, Brogden Kim A, Burns Trudy L, Sutterwala Fayyaz S, Ferguson Polly J
Abstract excerpt
Chronic recurrent multifocal osteomyelitis (CRMO) is a human autoinflammatory disorder that primarily affects bone. Missense mutation (L98P) of proline-serine-threonine phosphatase-interacting protein 2 (Pstpip2) in mice leads to a disease that is phenotypically similar to CRMO called chronic multifocal osteomyelitis (cmo). Here we show that deficiency of IL-1RI in cmo mice resulted in a significant reduction in...
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