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Article

Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.

The Journal of biological chemistry - 15 Feb 2013

Wang Donghai, Höing Susanne, Patterson Heide Christine, Ahmad Umtul M, Rathinam Vijay A K, Rajewsky Klaus, Fitzgerald Katherine A, Golenbock Douglas T

Abstract excerpt

Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne Syndrome (PAPA syndrome) is an autoinflammatory disease caused by aberrant production of the proinflammatory cytokine interleukin-1. Mutations in the gene encoding proline serine threonine phosphatase-interacting protein-1 (PSTPIP1) have been linked to PAPA syndrome. PSTPIP1 is an adaptor protein that interacts with PYRIN, the protein encoded by the Mediterranean...

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Source

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Identifiers

PMID: 23293022
DOI: 10.1074/jbc.M112.443077
PMCID: PMC3576065

Genes

PSTPIP1
MEFV

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.PMID 23293022Read ↗

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Excess Serum Interleukin-18 Distinguishes Patients with Pathogenic Mutations in <i>PSTPIP1</i>Semantic proximity Read ↗

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