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Article

PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts.

Blood - 11 Oct 2012

Chitu Violeta, Nacu Viorel, Charles Julia F, Henne William M, McMahon Harvey T, Nandi Sayan, Ketchum Halley, Harris Renee, Nakamura Mary C, Stanley E Richard

Abstract excerpt

Missense mutations that reduce or abrogate myeloid cell expression of the F-BAR domain protein, proline serine threonine phosphatase-interacting protein 2 (PSTPIP2), lead to autoinflammatory disease involving extramedullary hematopoiesis, skin and bone lesions. However, little is known about how PSTPIP2 regulates osteoclast development. Here we examined how PSTPIP2 deficiency causes osteopenia and bone lesions,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22923495
DOI: 10.1182/blood-2012-04-425595
PMCID: PMC3471520

Genes

PSTPIP2
MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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PSTPIP2 deficiency in mice causes osteopenia and increased differentiation of multipotent myeloid precursors into osteoclasts.PMID 22923495Read ↗

Increased neutrophil infiltration, IL-1 production and a SAPHO syndrome-like phenotype in PSTPIP2-deficient mice.Semantic proximity Read ↗

Regulation of neutrophil NADPH oxidase by PSTPIP2 affects bone damage in murine autoinflammatory osteomyelitisSemantic proximity Read ↗

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Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis.Semantic proximity Read ↗

Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice.Semantic proximity Read ↗

Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory diseaseSemantic proximity Read ↗

Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.Semantic proximity Read ↗

NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β–mediated osteomyelitisSemantic proximity Read ↗

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The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages.Semantic proximity Read ↗

Alarming consequences - autoinflammatory disease spectrum due to mutations in proline-serine-threonine phosphatase-interacting protein 1.Semantic proximity Read ↗

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