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Article

Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease

5 Jan 2006

Abstract excerpt

Macrophage actin-associated tyrosine phosphorylated protein (MAYP)/PSTPIP2, a PCH protein, is involved in the regulation of macrophage motility. Mutations in a closely related gene, PSTPIP1/CD2BP1, cause a dominantly inherited autoinflammatory disorder known as PAPA syndrome. A mutant mouse obtained by chemical mutagenesis exhibited an autoinflammatory disorder characterized by macrophage infiltration and...

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Identifiers

PMID: 16397132
DOI: 10.1182/blood-2005-09-3556

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Related research

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Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory diseasePMID 16397132Read ↗

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