Integrating the Idylla™ System Alongside a Real-Time Polymerase Chain Reaction and Next-Generation Sequencing for Investigating Gene Fusions in Pleural Effusions from Non-Small-Cell Lung Cancer Patients: A Pilot Study.

doi:10.3390/ijms25147594

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Integrating the Idylla™ System Alongside a Real-Time Polymerase Chain Reaction and Next-Generation Sequencing for Investigating Gene Fusions in Pleural Effusions from Non-Small-Cell Lung Cancer Patients: A Pilot Study.

International journal of molecular sciences - 11 Jul 2024

Scarpino Stefania, Leone Alvaro, Galafate Dino, Pepe Francesco, Malapelle Umberto, Villani Sandra, Giarnieri Enrico, Maurizi Giulio, De Vitis Claudia, Mancini Rita, Mancini Massimiliano, Di Napoli Arianna, Vecchione Andrea, Pilozzi Emanuela

Abstract excerpt

Malignant pleural effusion (MPE) from patients with advanced non-small-cell lung cancer (NSCLC) has been proven valuable for molecular analysis; however, simultaneous detection of driver fusions in MPE is still challenging. In this study, we investigated the Idylla™ GeneFusion Panel, a stand-alone test in tissue samples, in the evaluation of ALK, ROS1, RET and MET ex14 skipping mutations in MPE and compared its...

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PMID: 39062837
DOI: 10.3390/ijms25147594
PMCID: PMC11277451

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