Article
Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis.
Biochemistry - 18 Feb 2020
Smith Carl J, Wagner Andrew G, Stagnitta Robert T, Xu Zihan, Pezzullo John L, Giner José-Luis, Xie Jian, Covey Douglas F, Wang Chunyu, Callahan Brian P
Abstract excerpt
Hedgehog proteins, a family of vital cell signaling factors, are expressed in precursor form, which requires specialized autoprocessing, called cholesterolysis, for full biological activity. Cholesterolysis occurs in cis through the action of the precursor's C-terminal enzymatic domain, HhC. In this work, we describe HhC activator compounds (HACs), a novel class of noncovalent modulators that induce...
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