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Article

Endocannabinoid enzyme engineering: soluble human thio-monoacylglycerol lipase (sol-S-hMGL).

ACS chemical neuroscience - 16 May 2012

Karageorgos Ioannis, Zvonok Nikolai, Janero David R, Vemuri V Kiran, Shukla Vidyanand, Wales Thomas E, Engen John R, Makriyannis Alexandros

Abstract excerpt

In the mammalian central nervous system, monoacylglycerol lipase (MGL) is principally responsible for inactivating the endocannabinoid signaling lipid 2-arachidonoylglycerol (2-AG) and modulates cannabinoid-1 receptor (CB1R) desensitization and signal intensity. MGL is also a drug target for diseases in which CB1R stimulation may be therapeutic. To inform the design of human MGL (hMGL) inhibitors, we have...

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Identifiers

PMID: 22860208
DOI: 10.1021/cn3000263
PMCID: PMC3400385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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