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Article

Reducing Hypothalamic Stem Cell Senescence Protects against Aging-Associated Physiological Decline.

Cell metabolism - 3 Mar 2020

Xiao Yu-Zhong, Yang Mi, Xiao Ye, Guo Qi, Huang Yan, Li Chang-Jun, Cai Dongsheng, Luo Xiang-Hang

Abstract excerpt

Age-dependent loss of hypothalamic neural stem cells (htNSCs) is important for the pathological consequences of aging; however, it is unclear what drives the senescence of htNSCs. Here, we report that a long non-coding RNA, Hnscr, is abundantly expressed in the htNSCs of young mice but decreases markedly in middle-aged mice. We show that depletion of Hnscr is sufficient to drive the senescence of htNSCs and...

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Identifiers

PMID: 32004475
DOI: 10.1016/j.cmet.2020.01.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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