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Oxidized SOD1 accelerates cellular senescence in neural stem cells

27 Feb 2024

Abstract excerpt

BACKGROUND: Neural stem cells (NSCs), especially human NSCs, undergo cellular senescence characterized by an irreversible proliferation arrest and loss of stemness after prolonged culture. While compelling correlative data have been generated to support the oxidative stress theory as one of the primary determinants of cellular senescence of NSCs, a direct cause-and-effect relationship between the accumulation of...

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PMID: 38414053
DOI: 10.1186/s13287-024-03669-5

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